Silver‐catalysed A³‐coupling reactions in phenylacetic acid/alkylamine <i>N</i>‐oxide eutectic mixture under dielectric heating: An alternative approach to propargylamines

Abstract The development of alternative benign reaction conditions to perform multicomponent reactions is an interesting and desirable strategy increase the sustainability organic synthesis. In this paper, we report a new version A 3 ‐coupling MCR for preparation differently substituted propargylamines starting from aldehydes, alkynes amines in acidic DES as media, under dielectric heating, presence tetraaza‐macrocyclic silver complex catalyst. scope broad terms aldehyde partners. Electron‐rich phenylacetylenes are more reactive partners, whereas nature amine serious limitation only secondary cyclic tolerated.